Inhibitory Effects of Astragalus Polysaccharide on Proliferation of Human Lung Adenocarcinoma H1299 Cells via the Toll-Like Receptor 4/Myeloid Differentiation Factor 88/Nuclear Factor-Kappa B Signaling Pathway

To assess the inhibitory effects of Astragalus polysaccharide on proliferation human lung adenocarcinoma H1299 cells via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B signaling pathway. were treated with different concentrations polysaccharide. After 24 h and 48 h, cell counting kit-8 assay was employed to measure proliferation. The (25 μg/ml) invasion ability, migration ability apoptosis determined by transwell assay, wound healing assays, respectively. changes in expressions pathway-related proteins after treatment 25 μg/ml detected western blotting. inhibited a dose-dependent manner (p<0.05). rate significantly lower than that blank control group. polysaccharide, number invading through Matrigel into chamber reduced. higher Toll-like 4, myeloid 88 nuclear protein expression levels for those can inhibit proliferation, induce apoptosis, possibly being related reduction cells.